Immunohistochemical analysis of retinoblastoma cell phenotype using neuronal and glial cell markers
نویسندگان
چکیده
منابع مشابه
Immunohistochemical analysis of retinoblastoma cell phenotype using neuronal and glial cell markers.
Purpose: The cellular origin of retinoblastoma is uncertain as constituent tumor cells heterogeneously express markers of both immature and mature retinal cells. An immunohistochemical analysis of cellular origin may yield valuable insights into disease progression and treatment options. This study aimed to determine the cellular origin of retinoblastoma in a large case series and correlate the...
متن کاملImmunohistochemical evidence of neuronal and glial differentiation in retinoblastoma.
BACKGROUND The study sought to investigate the histogenesis of retinoblastoma. METHODS One hundred specimens of retinoblastomas were examined along with those of 18 astrocytic gliomas and 15 medulloblastomas to compare similarities of glial differentiation in retinoblastoma and the two types of brain tumour. Employing avidin-biotin immunoperoxidase technique, antibodies were applied against n...
متن کاملHuman embryonic and neuronal stem cell markers in retinoblastoma
PURPOSE Retinoblastoma (RB) is the most common intraocular tumor of early childhood. The early onset of RB, coupled with our previous findings of cancer stem cell characteristics in RB, led us to hypothesize that subpopulations of RB tumors harbor markers and behaviors characteristic of embryonic and neuronal origin. METHODS Our RB sources included: human pathological tissues, and the human R...
متن کاملNeuronal and glial cell biology.
us&y a cellular neurobiologist struggles to link findings made in simple cellular systems to the problems of the neuron. It is therefore gratifying when the flow is reversed and discoveries in neurons are seminal to the understanding of cell biology in general. This has been especially true for the past year in the field of membrane traffic in the nerve terminal. As reviewed by Martin (pp 626-6...
متن کاملNeuronal and glial cell biology
Kang Shen is an investigator in the Howard Hughes Medical Institute and an associate professor in the Department of Biology at Stanford University. His laboratory studies synapse formation in C. elegans and mammals with a focus on synaptic target recognition, presynaptic assembly, and axonal transport. Introduction The wiring of the nervous system is arguably the most challenging question in de...
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ژورنال
عنوان ژورنال: Arquivos Brasileiros de Oftalmologia
سال: 2016
ISSN: 0004-2749
DOI: 10.5935/0004-2749.20160111